- What is Anora Testing?
- Miscarriage Genetic Test
- Cost
- CPT Code
- Kit
- Results
What is Anora Testing?
Anora is a genetic test offered by Natera that analyzes tissue from a miscarriage (also known as products of conception, POC) to determine whether a chromosomal abnormality caused the pregnancy loss. It is the most commonly ordered test for recurrent miscarriages and can help couples understand whether future pregnancies may be affected by the same genetic issues.
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The test uses advanced single nucleotide polymorphism (SNP) microarray technology, which provides higher accuracy than traditional karyotyping. Anora testing does not require parental DNA, although including it may provide more precise results. By identifying whether a miscarriage was due to a random chromosomal error or a parental genetic condition, the test helps guide reproductive counseling and next steps in fertility planning.
Miscarriage Genetic Test
Anora is specifically designed to evaluate the genetic cause of a miscarriage. About 50–70% of miscarriages are due to chromosomal abnormalities, such as:
- Aneuploidy (extra or missing chromosomes, e.g., trisomy 21, monosomy X)
- Triploidy or tetraploidy
- Unbalanced chromosomal translocations
Traditional pathology may not explain why a miscarriage occurred, but Anora provides genetic confirmation. The test can be ordered after a first miscarriage, but it is particularly recommended for patients with recurrent pregnancy loss (RPL).
Cost
The cost of Anora testing varies depending on insurance coverage and testing arrangements:
- Estimated self-pay cost: $1,500 – $2,500 (USD)
- With insurance: Patients may pay as little as $0 if the test is covered.
- Natera also offers financial assistance and payment plans.
It is recommended that patients verify coverage with their insurance provider before ordering.
CPT Code
The CPT code commonly used for Anora testing is:
- 81228 – Cytogenomic SNP microarray analysis, for chromosomal abnormalities (may be billed with or without parental testing).
- 88233 / 88262 – May apply if additional tissue culture or chromosome analysis is required.
Exact coding may vary by laboratory and insurance provider.
Kit
Natera provides an Anora collection kit, which is typically available through fertility clinics, OB/GYN practices, or hospitals. The kit includes:
- Instructions for collecting miscarriage tissue
- Specimen container with preservative
- Shipping materials for sending to Natera’s laboratory
The kit is typically stored in the clinic until a miscarriage occurs. Physicians or fertility specialists collect the specimen during a procedure such as D&C (dilation and curettage) or from natural passage of tissue.
Results
Turnaround time: Approximately 1–2 weeks after specimen receipt.
Report includes:
- Whether a chromosomal abnormality caused the miscarriage
- The type of abnormality (e.g., trisomy, monosomy, translocation, triploidy)
- Whether the abnormality was random or inherited
- Implications for future pregnancies
If results are inconclusive (e.g., due to maternal cell contamination), Natera may request parental testing for clarification.
Clinical value: Anora results help patients and clinicians decide whether further fertility workup is needed or whether the miscarriage was most likely due to a random, non-recurring genetic error.
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