QNatal Test (Quest): CPT Code, Cost, Timing, Results, Gender & Advanced Genetic Screening

Content:

• What is QNatal Test (Quest)?
• CPT Code
• Cost
• Timing
• Results
• Gender
• Advanced Genetic Screening

What is QNatal Test (Quest)?

The QNatal test is a non-invasive prenatal test (NIPT) offered by Quest Diagnostics. It analyzes fragments of fetal DNA circulating in the mother’s blood to screen for common chromosomal abnormalities, such as trisomy 21 (Down syndrome), trisomy 18 (Edwards syndrome), and trisomy 13 (Patau syndrome). It is performed as a simple maternal blood draw, usually in the first trimester, and does not pose risks associated with invasive procedures like amniocentesis.

Unlike standard first-trimester screenings, QNatal offers higher sensitivity and specificity by directly analyzing cell-free DNA (cfDNA). It can also provide information about fetal sex and other genetic conditions depending on the option chosen. The test is typically recommended for women with higher-risk pregnancies, but many providers now offer it broadly to expectant mothers who want more detailed information early in pregnancy.

CPT Code

The CPT (Current Procedural Terminology) code is an important detail for insurance billing and documentation. For the QNatal Advanced test, the most commonly used CPT code is 81420, which refers to non-invasive prenatal DNA-based screening for trisomy 21, 18, and 13.

In some cases, additional CPT codes may apply if expanded screening panels are ordered or if special reporting is needed. Patients should confirm with their provider or Quest Diagnostics regarding exact coding, since this directly affects insurance coverage and out-of-pocket cost. Having the correct CPT code ensures smooth billing and reduces claim denials.

Cost

The cost of the QNatal test can vary depending on insurance coverage, location, and whether additional genetic panels are ordered. On average, without insurance, the test may cost between $800 to $2,000. With insurance, many patients pay a reduced rate, sometimes as low as $200 or less, depending on their plan and medical necessity documentation.

Quest Diagnostics often provides financial assistance or self-pay pricing options for patients who are uninsured or underinsured. It is important to check with both the testing lab and the insurance provider to understand exact costs before testing, especially since coverage policies for NIPT can vary widely.

Timing

The QNatal test can be performed as early as 10 weeks of pregnancy. This early testing window allows parents and healthcare providers to identify potential genetic concerns in the first trimester, giving more time for planning and decision-making.

Because the test analyzes fetal DNA fragments in maternal blood, earlier testing ensures that enough DNA is present to achieve accurate results. Performing the test before 10 weeks may lead to insufficient fetal fraction, increasing the chance of inconclusive results. For this reason, Quest generally recommends waiting until 10 weeks gestation for the most reliable outcome.

Results

Results from the QNatal test are typically available within 5–10 business days after the sample is collected and received by Quest Diagnostics. Results are sent directly to the ordering healthcare provider, who then shares them with the patient.

The report provides a clear risk assessment for major trisomies and other chromosomal abnormalities depending on the panel ordered. Results are classified as “low risk,” “increased risk,” or “no result” if the sample quality was insufficient. In cases of abnormal or inconclusive findings, additional confirmatory testing such as chorionic villus sampling (CVS) or amniocentesis may be recommended.

Gender

One of the optional features of the QNatal test is determining the baby’s sex (gender). Since the test analyzes fetal DNA, it can identify the presence or absence of the Y chromosome. If Y chromosome material is detected, the baby is male; if not, the baby is female.

This information is generally over 99% accurate when reported, making it more reliable than early ultrasound. Gender results are usually included with the rest of the genetic screening findings, though some parents may choose not to receive this information if they prefer to wait until birth.

Advanced Genetic Screening

Beyond the standard trisomy panel, QNatal offers expanded screening options. These may include screening for microdeletions (small missing pieces of chromosomes) and sex chromosome abnormalities such as Turner syndrome (45,X), Klinefelter syndrome (47,XXY), and others.

Advanced screening provides a broader view of potential genetic issues, though not all conditions are included. It is important to understand that NIPT like QNatal is a screening test, not a diagnostic test. Abnormal findings must always be confirmed with diagnostic procedures. For parents seeking early, non-invasive insights into their baby’s genetic health, QNatal Advanced is one of the most comprehensive options available through a major laboratory.